In this episode, Dr. Puder addresses the fascinating realm of schizophrenia with Dr. Cummings, a previous guest in the show. Dr. Cummings is a psychiatrist with a wealth of experience from working at Patton State Hospital in California, one of the biggest forensic hospitals in the world.
Swedish survey about misperceptions of the environment found that roughly 50% of the population have had misperceptions that could be considered psychotic in nature.
The Loss of Brain in Schizophrenia
Schizophrenic patients lose 2% of brain mass per year for the first 5 year in the course of illness.
Living with Schizophrenia and Perception of Reality
Are Negative Symptoms in Schizophrenia Precipitated by Medications?
The Pathology, Biology, and Genetics of Schizophrenia
Cannabis Use and Risk For Schizophrenia
Counter-arguments Against Robert Whitaker’s “Anatomy of an Epidemic”
Emil Kraepelin, and the Early Studies on Schizophrenia
The majority of schizophrenic patients during Kraepelin’s observation became vegetative in their 40s.
After the advent of antipsychotic medications, schizophrenic patients are able to function until their 70s-80s
Gitlin 2001 Neuroleptic Discontinuation Study
Exacerbation or relapse was almost universal within 2 years in those who discontinued antipsychotics
Schizophrenia Prevention in High Risk Population
Australian study on children of schizophrenic parents (Yung, 2011)
Australian Study on Children of Schizophrenic Parents
Crime, Violence, Mass Shootings and Schizophrenia
Medical Management of Schizophrenia
1st Break Psychosis
Long-acting Injectable Antipsychotics in Early Illness
Exercise for schizophrenia increased hippocampal size by 12% vs. -1% for non exercising groups of patients (Pajonk, 2010)
Lifestyle, Diet Optimization
Gitlin, M., Nuechterlein, K., Subotnik, K. L., Ventura, J., Mintz, J., Fogelson, D. L., ... & Aravagiri, M. (2001). Clinical outcome following neuroleptic discontinuation in patients with remitted recent-onset schizophrenia. American Journal of Psychiatry, 158(11), 1835-1842.
Pajonk, F. G., Wobrock, T., Gruber, O., Scherk, H., Berner, D., Kaizl, I., ... & Backens, M. (2010). Hippocampal plasticity in response to exercise in schizophrenia. Archives of general psychiatry, 67(2), 133-143.